関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Bromocycloheptane | HCID 16992 | — |
| 反応物 | Sodium bis(trimethylsilyl)amide | HCID 2724254 | — |
| 反応物 | methyl 3-(1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropanoate | HCID 59251051 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | methyl 3-(1-cycloheptyl-1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropanoate | HCID 68702551 | 60% |
反応手順
Methyl 3-(1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropanoate (500 mg, 1.62 mmol, prepared in Synthetic Intermediate III(c)) was dissolved in 5 mL DMSO and NaHMDS (2.4 mL, 2.4 mmol, 1.0 M in THF) was added followed by bromocycloheptane (446 uL, 3.25 mmol). The reaction was heated overnight at 85° C. The reaction was quenched with TFA and purified by HPLC to give methyl 3-(1-cycloheptyl-1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropanoate (393 mg, 60%). (M+H)+=405.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08198311B2 |
|---|
| 出典データセット | uspto-grants-2012_06 |
|---|
| ORD ID | ord-60fecc13f5284888bf25953c32ff45cc |
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| 出典メモ | uspto-grants-2012_06 |
|---|
