Potassium Carbonate → 3,9-Difluoro-5-[(4-methoxyphenyl)sulfonyl]-6-methyl-5,6-dihydrophenanthridine

HRID 2181910ノート

反応式

HRID 2181910 の反応式
F[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[CH:16]([NH:18][S:19]([C:22]1[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][CH:23]=1)(=[O:21])=[O:20])[CH3:17].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[F:8][C:6]1[CH:7]=[CH:2][C:3]2[C:9]3[C:10]([CH:16]([CH3:17])[N:18]([S:19]([C:22]4[CH:23]=[CH:24][C:25]([O:28][CH3:29])=[CH:26][CH:27]=4)(=[O:20])=[O:21])[C:4]=2[CH:5]=1)=[CH:11][CH:12]=[C:13]([F:15])[CH:14]=3

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 22482340N-[1-(2',4',5-Trifluoro-1,1'-biphenyl-2-yl)ethyl]-4-methoxybenzenesulfonamide

生成物 1

HCID 224823443,9-Difluoro-5-[(4-methoxyphenyl)sulfonyl]-6-methyl-5,6-dihydrophenanthridine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

The title compound was prepared from N-[1-(2′,4′,5-trifluoro-1,1′-biphenyl-2-yl)ethyl]-4-methoxybenzenesulfonamide (161 mg, 0.38 mmol), anhydrous N,N-dimethylformamide (1 mL), and potassium carbonate (106 mg, 0.76 mmol) according to the procedure and in the same manner as described in Example 105, step d resulting in the isolation of 143 mg (93%) of a white solid. This material was used without further purification in Example 114, step e;

出典と根拠

ORDレコード
ord-8244310883bd41f383daa498fae65b9c
出典データセット
uspto-grants-2005_05
特許番号
US06894061B2

反応ノート

読み込み中…