Hydrochloric Acid → 2-[(3-Chlorophenyl)methoxy]-6-(piperazin-1-yl)pyrazine--hydrogen chloride (1/1)

HRID 2182131ノート

反応式

HRID 2182131 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:19]=[CH:20][CH:21]=1)[CH2:5][O:6][C:7]1[N:12]=[C:11]([N:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)[CH:10]=[N:9][CH:8]=1.Cl.CCCCCC>C(Cl)Cl.CCOCC>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([CH:19]=[CH:20][CH:21]=1)[CH2:5][O:6][C:7]1[N:12]=[C:11]([N:13]2[CH2:14][CH2:15][NH:16][CH2:17][CH2:18]2)[CH:10]=[N:9][CH:8]=1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 8058HexaneHCID 9901086CP-809101

生成物 1

HCID 569722202-[(3-Chlorophenyl)methoxy]-6-(piperazin-1-yl)pyrazine--hydrogen chloride (1/1)

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 6344Dichloromethane溶媒

実験手順

To a solution of 6′-(3-chloro-benzyloxy)-3,4,5,6-tetrahydro-2H-[1,2′]bipyrazinyl (1-A) in CH2Cl2 (4 mL) was added dropwise 1M HCl in ether (1.5 mL) and then hexane (4 mL) was added. The solid was collected and dried to give the hydrochloride salt (1-B) (300 mg).

後処理

  1. customThe solid was collected
  2. customdried

出典と根拠

ORDレコード
ord-0c7cb6196e134225890dbe8a5c13dfb4
出典データセット
uspto-grants-2005_05
特許番号
US06894050B2

反応ノート

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