HCID 21948929、化合物 → HCID 21948915、化合物

HRID 2182699ノート

反応式

HRID 2182699 の反応式
[C:1]([O:4][CH2:5][C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][C:12]=2[N+:16]([O-])=O)[N:7]=1)(=[O:3])[CH3:2]>CC(C)=O.[Ni]>[C:1]([O:4][CH2:5][C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][C:12]=2[NH2:16])[N:7]=1)(=[O:3])[CH3:2]

参加物

4

反応物 1

HCID 21948929HCID 21948929、化合物

生成物 1

HCID 21948915HCID 21948915、化合物

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 180Acetone溶媒2 回

実験手順

Under hydrogen atmosphere, a solution that consists of 410 mg (1.67 mol) of 2-(acetoxymethyl)-5-nitroquinoline in 61 ml of acetone can be stirred in the presence of 410 mg of Raney nickel for 2 hours at room temperature. It is suctioned off on Celite and rewashed with acetone. After removal of the solvent and subsequent chromatography on silica gel with hexane-ethyl acetate (10-100%), 230 mg (64% of theory) of the product is obtained.

後処理

  1. customAfter removal of the solvent and subsequent chromatography on silica gel with hexane-ethyl acetate (10-100%), 230 mg (64% of theory) of the product
  2. customis obtained

出典と根拠

ORDレコード
ord-cf726dd22292425289dbe5d1bb41f3a8
出典データセット
uspto-grants-2005_05
特許番号
US06897224B2

反応ノート

読み込み中…