関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | trans-beta-Bromostyrene | HCID 5314126 | — |
| 反応物 | HCID 178506617 | HCID 178506617 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 触媒 | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 溶媒 | Perfluorohexane | HCID 9639 | — |
| 生成物 | trans-Stilbene | HCID 638088 | — |
反応手順
In an illustrative example, a coupling reaction was conducted between (E)-2-bromostyrene (PhCH═CHBr) and phenylzinc iodide (PhZnI) promoted by a fluorous palladium catalyst. The catalyst was prepared from Pd2(dba)3 and the known fluorous phosphine (p-C6F13CH2CH2C6H4)3P. A mixture of the catalyst in FC-72 was contacted in a U-tube with a first organic phase containing (E)-2-bromostyrene in acetonitrile and a second organic phase containing phenylzinc iodide in THF. After one day at ambient temperature, each organic phase was removed and subjected to standard aqueous workup. Unreacted (E)-2-bromostyrene was recovered from the first organic phase while the coupled reaction product, (E)-stilbene (PhCH═CHPh) was isolated from the second organic phase.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06897331B2 |
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| 出典データセット | uspto-grants-2005_05 |
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| ORD ID | ord-4807387aed194981af52ac32c94e23b4 |
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| 出典メモ | uspto-grants-2005_05 |
|---|
