Hydrochloric Acid → (S)-1-[3-(6-methyl-pyridin-3-yloxy)-phenyl]ethylamine

HRID 2183459

反応式

HRID 2183459 の反応式
C(OC(=O)[NH:7][C@H:8]([C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([O:16][C:17]2[CH:18]=[N:19][C:20]([CH3:23])=[CH:21][CH:22]=2)[CH:11]=1)[CH3:9])(C)(C)C.Cl>CCOCC.CO>[CH3:23][C:20]1[N:19]=[CH:18][C:17]([O:16][C:12]2[CH:11]=[C:10]([C@@H:8]([NH2:7])[CH3:9])[CH:15]=[CH:14][CH:13]=2)=[CH:22][CH:21]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 60004122(S)-{1-[3-(6-Methyl-pyridin-3-yloxy)-phenyl]-ethyl}-carbamic acid tert-butyl ester

生成物 1

HCID 60004124(S)-1-[3-(6-methyl-pyridin-3-yloxy)-phenyl]ethylamine収率 141.6%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 3283Diethyl Ether溶媒

実験手順

(S)-{1-[3-(6-Methyl-pyridin-3-yloxy)-phenyl]-ethyl}-carbamic acid tert-butyl ester (3.45 g, 10.52 mmol), hydrogen chloride in ether (36.8 mL, 1.0M) and methanol (5 mL) was stirred at room temperature for 6 h. The reaction mixture was concentrated in vacuo to provide the title compound (3.4 g, quantitative yield) as yellow solid.

後処理

  1. concentrationThe reaction mixture was concentrated in vacuo

出典と根拠

ORDレコード
ord-e63ac5ecff554945914a4d7b418d4464
出典データセット
uspto-grants-2005_05
特許番号
US06900210B2

関連ノート

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