Hydrochloric Acid → HCID 60004113、化合物

HRID 2183466ノート

反応式

HRID 2183466 の反応式
C(OC(=O)[NH:7][C@H:8]([C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([NH:16][CH2:17][C:18]2[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=2)[CH:11]=1)[CH3:9])(C)(C)C.Cl>O1CCOCC1>[NH2:7][C@H:8]([C:10]1[CH:11]=[C:12]([NH:16][CH2:17][C:18]2[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=2)[CH:13]=[CH:14][CH:15]=1)[CH3:9]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 60004119HCID 60004119、化合物

生成物 1

HCID 60004113HCID 60004113、化合物収率 91.2%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A mixture of (S)-(1-{3-[(pyridin-3-ylmethyl)-amino]-phenyl}-ethyl)carbamic acid tert-butyl ester (3 g) and 9 mL of 4 N HCl in dioxane (20 mL) was heated at 60° for 2 h. The reaction mixture was concentrated in vacuo, and the residue was neutralized with 10 N NaOH followed by extraction with methylene chloride. The organic layer was washed with brine, dried over Na2SO4, and concentrated in vacuo to give the title compound (1.9 g) as an oil.

後処理

  1. temperaturewas heated at 60° for 2 h
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. extractionfollowed by extraction with methylene chloride
  4. washThe organic layer was washed with brine
  5. dry with materialdried over Na2SO4
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-6db0c547b261404a9d82c04c483b7d84
出典データセット
uspto-grants-2005_05
特許番号
US06900210B2

反応ノート

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