Phosphorus oxychloride → 4-Chloro-2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-5H-pyrrolo[3,2-d]pyrimidine

HRID 2183550

反応式

HRID 2183550 の反応式
[CH3:1][C:2]1[N:3]=[C:4](O)[C:5]2[N:10]([CH3:11])[CH:9]=[C:8]([C:12]3[C:17]([CH3:18])=[CH:16][C:15]([CH3:19])=[CH:14][C:13]=3[CH3:20])[C:6]=2[N:7]=1.O=P(Cl)(Cl)[Cl:24]>>[Cl:24][C:4]1[C:5]2[N:10]([CH3:11])[CH:9]=[C:8]([C:12]3[C:17]([CH3:18])=[CH:16][C:15]([CH3:19])=[CH:14][C:13]=3[CH3:20])[C:6]=2[N:7]=[C:2]([CH3:1])[N:3]=1

参加物

3

反応物 2

HCID 24813Phosphorus oxychlorideHCID 178424583HCID 178424583、化合物

生成物 1

HCID 224743134-Chloro-2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-5H-pyrrolo[3,2-d]pyrimidine

実験手順

A mixture of 2,5-dimethyl-7-(2,4,6-trimethylphenyl)-5H-pyrrolo[3,2-d]pyrimidin-4-ol (1 mmol) in POCl3 (1.3 ml) was heated at reflux until all the starting material were consumed (about 1-3 hours). The mixture was concentrated to dryness. The residue was porued into ice-water and extracted with ethyl acetate. The organic layer was dried and concentrated to dryness to give the title compound.

後処理

  1. temperaturewas heated
  2. temperatureat reflux until all the starting material
  3. customwere consumed (about 1-3 hours)
  4. concentrationThe mixture was concentrated to dryness
  5. extractionextracted with ethyl acetate
  6. customThe organic layer was dried
  7. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-7211b86f387546a1b45600ac4ed0f29c
出典データセット
uspto-grants-2005_05
特許番号
US06900217B2

関連ノート

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