Ethanol → 3-(Benzo[b]thiophen-4-yl)-5,6-dihydroimidazo[2,1-b]thiazole hydrochloride

HRID 2183592

反応式

HRID 2183592 の反応式
[S:1]1[CH:5]=[CH:4][C:3]2[C:6]([C:10](=O)[CH2:11][Cl:12])=[CH:7][CH:8]=[CH:9][C:2]1=2.[NH:14]1[CH2:18][CH2:17][NH:16][C:15]1=[S:19].C(O)C>C(O)(=O)C>[ClH:12].[S:1]1[CH:5]=[CH:4][C:3]2[C:6]([C:10]3[N:16]4[CH2:17][CH2:18][N:14]=[C:15]4[S:19][CH:11]=3)=[CH:7][CH:8]=[CH:9][C:2]1=2

参加物

5

反応物 3

HCID 702EthanolHCID 2723650EthylenethioureaHCID 224737991-(Benzo[b]thiophen-4-yl)-2-chloroethan-1-one

生成物 1

HCID 224738373-(Benzo[b]thiophen-4-yl)-5,6-dihydroimidazo[2,1-b]thiazole hydrochloride収率 107.5%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A mixture of 1-(benzo[b]thiophen-4-yl)-2-chloroethan-1-one (1.15 g), 2-imidazolidinethione (0.57 g), ethanol (10 ml) and acetic acid (6 ml) was heated under reflux for 18 hours then cooled to ambient temperature. The solvents were removed in vacuo and the residue was triturated with ether (30 ml). The resulting solid was collected by filtration, washed with ether (30 ml) and dried in vacuo at 40° C. to give 3-(benzo[b]thiophen-4-yl)-5,6-dihydroimidazo[2,1-b]thiazole hydrochloride (1.73 g) as a cream solid, m.p. 246-249° C.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 18 hours
  3. customThe solvents were removed in vacuo
  4. customthe residue was triturated with ether (30 ml)
  5. filtrationThe resulting solid was collected by filtration
  6. washwashed with ether (30 ml)
  7. customdried in vacuo at 40° C.

出典と根拠

ORDレコード
ord-5817eaaee1a84fc79c01a652dd385234
出典データセット
uspto-grants-2005_05
特許番号
US06900216B2

関連ノート

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