Ethanol → HCID 22474170、化合物

HRID 2183632ノート

反応式

HRID 2183632 の反応式
[S:1]1[C:5]([C:6](=O)[CH2:7][Br:8])=[CH:4][C:3]2[CH:10]=[CH:11][CH:12]=[CH:13][C:2]1=2.[NH:14]1[CH2:18][CH2:17][NH:16][C:15]1=[S:19].C(O)C>C(O)(=O)C>[BrH:8].[S:1]1[C:5]([C:6]2[N:16]3[CH2:17][CH2:18][N:14]=[C:15]3[S:19][CH:7]=2)=[CH:4][C:3]2[CH:10]=[CH:11][CH:12]=[CH:13][C:2]1=2

参加物

5

反応物 3

HCID 702EthanolHCID 2723650EthylenethioureaHCID 27952581-(1-Benzothiophen-2-yl)-2-bromoethan-1-one

生成物 1

HCID 22474170HCID 22474170、化合物収率 75.6%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A mixture of 1-(benzo[b]thiophen-2-yl)-2-bromoethan-1-one (21.96 g), 2-imidazolidinethione (7.81 g) and ethanol (300 ml) was heated under reflux for 10 minutes. Acetic acid (150 ml) was added, then the mixture was heated under reflux for 18 hours and allowed to cool to ambient temperature. The resulting solid was collected by filtration, washed with ethanol (50 ml) and ether (50 ml), then dried in vacuo at 100° C. for 3 hours to give 3-(benzo[b]thiophen-2-yl)-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide (19.6 g) as a light brown solid, m.p. 275-285° C. (decomposes).

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 10 minutes
  3. temperaturethe mixture was heated
  4. temperatureunder reflux for 18 hours
  5. filtrationThe resulting solid was collected by filtration
  6. washwashed with ethanol (50 ml) and ether (50 ml)
  7. customdried in vacuo at 100° C. for 3 hours

出典と根拠

ORDレコード
ord-3b12617c00734856bfe4e0e0734ef99f
出典データセット
uspto-grants-2005_05
特許番号
US06900216B2

反応ノート

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