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3-Cyclohexylimidazo[1,5-a]pyrazine → 3-cyclohexyl-5H,6H,7H,8H-imidazo[1,5-a]pyrazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Cyclohexylimidazo[1,5-a]pyrazine | HCID 21983665 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Adams' catalyst | HCID 345198 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3-cyclohexyl-5H,6H,7H,8H-imidazo[1,5-a]pyrazine | HCID 21983608 | 87.5% |
反応手順
A solution of 3-cyclohexyl-imidazo[1,5-a]pyrazine 8a (960 mg, 4.4 mmol) in 25 ml ethanol was treated with 100 mg Adam's catalyst and stirred vigorously under one atmosphere of hydrogen for 18 hr. The mixture was filtered through a pad of Celite®. The filtrate was concentrated in vacuo to yield 790 mg of 3-cyclohexyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine 9a as a greenish-yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06900220B2 |
| 出典データセット | uspto-grants-2005_05 |
| ORD ID | ord-b160e3c02ae6415d9a8fb16a78205e97 |
| 出典メモ | uspto-grants-2005_05 |