反応式
[C:1]1([CH3:16])[CH:6]=[CH:5][CH:4]=[C:3]([N:7]2[C:15]3[CH2:14][CH2:13][NH:12][CH2:11][C:10]=3[N:9]=[CH:8]2)[CH:2]=1.Cl[C:18]1[NH:27][C:26](=[O:28])[C:25]2[C:20](=[CH:21][C:22]([O:31][CH3:32])=[C:23]([O:29][CH3:30])[CH:24]=2)[N:19]=1.C(N(CC)CC)C.C(O)C>COC(O)C>[CH3:30][O:29][C:23]1[CH:24]=[C:25]2[C:20](=[CH:21][C:22]=1[O:31][CH3:32])[N:19]=[C:18]([N:12]1[CH2:13][CH2:14][C:15]3[N:7]([C:3]4[CH:2]=[C:1]([CH3:16])[CH:6]=[CH:5][CH:4]=4)[CH:8]=[N:9][C:10]=3[CH2:11]1)[NH:27][C:26]2=[O:28]参加物
6
反応物 4
生成物 1
試薬・触媒・溶媒 1
反応条件
- 温度
- 100 °C
実験手順
A mixture of 1-m-tolyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine 18a (100 mg, 0.5 mmol), 2-chloro-6,7-dimethoxy-3H-quinazolin-4-one 1b (100 mg, 0.4 mmol), and triethylamine (140 μL, 1.0 mmol) in 10 mL methoxyethanol was heated at 100° C. under nitrogen for 12 hr. The mixture was pumped to constant weight. The resulting residue was slurried with hot ethanol and allowed to reach ambient temperature. Vacuum filtration provided 95 mg of 6,7-dimethoxy-2-(1-m-tolyl-1,4,6,7-tetrahydro-imidazo[4,5-c]pyridin-5-yl)-3H-quinazolin-4-one, 601, [M+H]+=418, as a white solid.
後処理
- customto reach ambient temperature
- filtrationVacuum filtration
出典と根拠
- ORDレコード
- ord-10b30f30a6b34483809b31f83eb5d43d
- 出典データセット
- uspto-grants-2005_05
- 特許番号
- US06900220B2
関連ノート
読み込み中…