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1-Chloro-4-(chloromethyl)benzene → 4-Chlorobenzyl N-methyl-N-phenylglycinate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Chloro-4-(chloromethyl)benzene | HCID 7723 | — |
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | N-Methyl-N-phenyl-glycine | HCID 420843 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 4-Chlorobenzyl N-methyl-N-phenylglycinate | HCID 22475619 | 68% |
反応手順
The product from step 2 (220 mg, 1.3 mmol) was dissolved in DMF (7 mL) and Cs2CO3 (652 mg, 2.0 mmol) added, followed by 4-chlorobenzyl chloride (214 mg, 1.3 mmol). Allow reaction mixture to stir at ambient temperature over 18 hours. The reaction mixture was diluted with EtOAc and washed several times with brine. The organic layer was dried (Na2SO4), filtered and concentrated to afford the title compound as a yellow oil (68%). MS (ES+) m/z 290 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06900244B2 |
| 出典データセット | uspto-grants-2005_05 |
| ORD ID | ord-438b7ff164b94e54ab70879eeafb9775 |
| 出典メモ | uspto-grants-2005_05 |