Cyclohexanone → Ethyl 8-amino-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylate

HRID 2184299ノート

反応式

HRID 2184299 の反応式
[CH2:1]([O:3][C:4](=[O:13])[C:5]1[CH:10]=[C:9]([NH2:11])[C:8]([NH2:12])=[N:7][CH:6]=1)[CH3:2].[C:14]1(=O)[CH2:19]CC[CH2:16][CH2:15]1>>[NH2:11][C:9]1[C:8]2[N:7]([C:14]([CH3:19])=[C:15]([CH3:16])[N:12]=2)[CH:6]=[C:5]([C:4]([O:3][CH2:1][CH3:2])=[O:13])[CH:10]=1

参加物

3

反応物 2

HCID 7967CyclohexanoneHCID 9877541Ethyl 5,6-diaminonicotinate

生成物 1

HCID 9942738Ethyl 8-amino-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylate

反応条件

温度
100 °C

実験手順

To a suspension of 5,6-diamino-nicotinic acid ethyl ester (1 eq., 5.0 g) in cyclohexanone (50 ml) bromobutanone (1.4 equiv., 5.95 g) was added over 15 min. The dark brown mixture was heated to 100° C. (inner temperature) and stirred 1.5 h at this temperature. The mixture was cooled to room temperature and the light brown solid was filtered off and was washed with TBME (20 ml). Drying under reduced pressure at 45° C. Yield: 5.06 g (65%).

後処理

  1. additionwas added over 15 min
  2. temperatureThe mixture was cooled to room temperature
  3. filtrationthe light brown solid was filtered off
  4. washwas washed with TBME (20 ml)
  5. customDrying under reduced pressure at 45° C

出典と根拠

ORDレコード
ord-8ad388311dcc40bf9016f02e0007224d
出典データセット
uspto-grants-2005_05
特許番号
US06900324B2

反応ノート

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