Methanol → Methyl 3-benzoylbenzoate

HRID 2184324ノート

反応式

HRID 2184324 の反応式
[C:1]([C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][CH:17]=1)[C:12]([OH:14])=[O:13])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.OS(O)(=O)=O.[CH3:23]O>C(OCC)(=O)C>[CH3:23][O:13][C:12](=[O:14])[C:11]1[CH:15]=[CH:16][CH:17]=[C:9]([C:1](=[O:8])[C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH:10]=1

参加物

5

反応物 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 1013863-Benzoylbenzoic acid

生成物 1

HCID 349621Methyl 3-benzoylbenzoate

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

3-Benzoyl-benzoic acid (5.12 g, 22.6 mmol) was stirred in methanol (45 mL) with conc. H2SO4 (2.0 mL) for 18 h at 60° C. The reaction mixture was diluted with ethyl acetate and then washed with an aqueous NaHCO3 solution. The organic layer was dried over MgSO4, filtered, and concentrated to provide 3-benzoyl-benzoic acid methyl ester (5.4 g, 22.6 mmol) in quantitative yield as a yellow oil.

後処理

  1. washwashed with an aqueous NaHCO3 solution
  2. dry with materialThe organic layer was dried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-03731bebb93a432aab22d224d6568222
出典データセット
uspto-grants-2005_05
特許番号
US06900336B2

反応ノート

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