Methylamine → 3-{4-[(4-Fluorophenyl)methoxy]phenyl}-N-methylprop-2-enamide

反応式

[F:1][C:2]1[CH:20]=[CH:19][C:5]([CH2:6][O:7][C:8]2[CH:13]=[CH:12][C:11]([CH:14]=[CH:15][C:16](O)=[O:17])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[CH3:21][NH2:22]>>[F:1][C:2]1[CH:20]=[CH:19][C:5]([CH2:6][O:7][C:8]2[CH:13]=[CH:12][C:11]([CH:14]=[CH:15][C:16]([NH:22][CH3:21])=[O:17])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1

参加物

反応物 2

HCID 6329Methylamine

HCID 8053823-[4-[(4-fluorophenyl)methoxy]phenyl]prop-2-enoic Acid

生成物 1

HCID 686690963-{4-[(4-Fluorophenyl)methoxy]phenyl}-N-methylprop-2-enamide収率 21%

実験手順

The title compound is prepared in analogy to example 12 b) from 3-[4-(4-fluoro-benzyloxy)-phenyl]-acrylic acid and methylamine. Yield=21%. Colorless solid. MS: m/e=286.0 (M++H).

出典と根拠

ORDレコード: ord-cb35523b78bd4be2ad4c83d9613ee1a8
出典データセット: uspto-grants-2005_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06900354B2

反応ノート

読み込み中…