関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methyl cyanoacetate | HCID 7747 | — |
| 反応物 | o-Methylvalerolactim | HCID 138567 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Cyano-2-piperidinylidene-ethanoic acid methyl ester | HCID 69042496 | 80% |
反応手順
A mixture of 2,3,4,5-tetrahydro-6-methoxypyridine (1.1 g, 9.72 mmol) and cyanoacetic acid methyl ester (1 g, 10.1 mmol) in 40 mL THF was heated at 70° C. overnight. The reaction was cooled, and solvent was removed in vacuo. The resulting residue was purified on flash column to afford cyano-2-piperidinylidene-ethanoic acid methyl ester (1.4 g, 80%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08198456B2 |
|---|
| 出典データセット | uspto-grants-2012_06 |
|---|
| ORD ID | ord-0b3505796c35498b9aa8c9bd385cf3ef |
|---|
| 出典メモ | uspto-grants-2012_06 |
|---|
