化工社化工社 化学情報印刷レポート · 研究参考用
Hydrazine → 1H-Pyrazolo(4,3-b)pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrazine | HCID 9321 | — |
| 反応物 | 3-Fluoro-2-pyridinecarboxaldehyde | HCID 11344017 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 1H-Pyrazolo(4,3-b)pyridine | HCID 21643653 | 60.4% |
反応手順
A mixture of 3-fluoro-2-pyridinecarboxaldehyde (4 g, 32 mmol) and hydrazine (20.5 g) was kept at 115° C. for 7 hr, then cooled to rt. The reaction mixture was diluted with water and extracted with EtOAc. The organic phases were combined, washed with brine, and dried. Concentration followed by flash chromatography afforded 1H-pyrazolo[4,3-b]pyridine (2.3 g, 60.4%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08198456B2 |
| 出典データセット | uspto-grants-2012_06 |
| ORD ID | ord-2a2bc17e86064d979af9365c6fef2b04 |
| 出典メモ | uspto-grants-2012_06 |