1-Indanol → Indanyl 3-{[2-(Acetylamino)ethylthio]methyl}-4-oxo-4-(3-pyridyl)butanoate

反応式

[C:1]([NH:4][CH2:5][CH2:6][S:7][CH2:8][CH:9]([C:14](=[O:21])[C:15]1[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=1)[CH2:10][C:11]([OH:13])=[O:12])(=[O:3])[CH3:2].[CH:22]1(O)[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH2:24][CH2:23]1>>[C:1]([NH:4][CH2:5][CH2:6][S:7][CH2:8][CH:9]([C:14](=[O:21])[C:15]1[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=1)[CH2:10][C:11]([O:13][CH:22]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH2:24][CH2:23]1)=[O:12])(=[O:3])[CH3:2]

参加物

反応物 2

HCID 228191-Indanol

HCID 99445253-{[2-(Acetylamino)ethylthio]methyl}-4-oxo-4-(3-pyridyl)butanoic acid

生成物 1

HCID 21340915Indanyl 3-{[2-(Acetylamino)ethylthio]methyl}-4-oxo-4-(3-pyridyl)butanoate収率 55%

実験手順

The title compound was prepared from 3-{[2-(acetylamino)ethylthio]methyl}-4-oxo-4-(3-pyridyl)butanoic acid and indanol as described in the above Example 26 in 55% yield; ESMS (M+1+) 427.

出典と根拠

ORDレコード: ord-cc15fec332ab421cb81194ea16dba3cd
出典データセット: uspto-grants-2002_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06399606B1

反応ノート

読み込み中…