4-(1-Acetylpiperidin-4-yl)furo[3,2-c]pyridine → 4-(4-Piperidinyl)furo[3,2-c]pyridine

HRID 2184804ノート

反応式

HRID 2184804 の反応式
C([N:4]1[CH2:9][CH2:8][CH:7]([C:10]2[C:15]3[CH:16]=[CH:17][O:18][C:14]=3[CH:13]=[CH:12][N:11]=2)[CH2:6][CH2:5]1)(=O)C>Cl>[NH:4]1[CH2:5][CH2:6][CH:7]([C:10]2[C:15]3[CH:16]=[CH:17][O:18][C:14]=3[CH:13]=[CH:12][N:11]=2)[CH2:8][CH2:9]1

参加物

3

反応物 1

HCID 183997294-(1-Acetylpiperidin-4-yl)furo[3,2-c]pyridine

生成物 1

HCID 183997754-(4-Piperidinyl)furo[3,2-c]pyridine

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

A solution of 2.7 g of the product obtained in Step D in 80 ml of HCl (4N) is heated at 100° C. for 12 hours and then cooled, washed with ether, and rendered basic to a pH of 10 by the addition of an aqueous sodium hydroxide solution. After extraction with dichloromethane, the organic phase is dried, filtered and then evaporated to dryness enabling the expected product to be obtained.

後処理

  1. temperaturecooled
  2. washwashed with ether
  3. additionrendered basic to a pH of 10 by the addition of an aqueous sodium hydroxide solution
  4. extractionAfter extraction with dichloromethane
  5. customthe organic phase is dried
  6. filtrationfiltered
  7. customevaporated to dryness
  8. customto be obtained

出典と根拠

ORDレコード
ord-258969c5832846a0bbc19303ffe905a4
出典データセット
uspto-grants-2002_06
特許番号
US06399616B1

反応ノート

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