Carbon tetrabromide → 1H-Indole, 5-bromo-3-(2-bromoethyl)-

HRID 2184822ノート

反応式

HRID 2184822 の反応式
C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[Br:20][C:21]1[CH:22]=[C:23]2[C:27](=[CH:28][CH:29]=1)[NH:26][CH:25]=[C:24]2[CH2:30][CH2:31]O.C(Br)(Br)(Br)[Br:34]>ClCCl>[Br:20][C:21]1[CH:22]=[C:23]2[C:27](=[CH:28][CH:29]=1)[NH:26][CH:25]=[C:24]2[CH2:30][CH2:31][Br:34]

参加物

5

反応物 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 1229565-Bromo-1H-indole-3-ethanol

生成物 1

HCID 183997061H-Indole, 5-bromo-3-(2-bromoethyl)-

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

A solution of 11.5 g of triphenylphosphine in 60 ml of dichloromethane is added to a solution, cooled to 0° C., of 4 g of the compound obtained in Step 1 and 7.5 g of carbon tetrabromide in 100 ml of dichloromethane. After stirring for 48 hours at ambient temperature, the reaction mixture is concentrated in vacuo. The residue obtained is chromatographed on silica gel (dichloromethane/cyclohexane: 80/20), enabling the expected product to be isolated.

後処理

  1. concentrationthe reaction mixture is concentrated in vacuo
  2. customThe residue obtained
  3. customis chromatographed on silica gel (dichloromethane/cyclohexane: 80/20)
  4. customto be isolated

出典と根拠

ORDレコード
ord-490ad3aae54f4bef8d6f7d1f68fa186d
出典データセット
uspto-grants-2002_06
特許番号
US06399616B1

反応ノート

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