Water → 5-Nitro-2-(piperazin-1-yl)benzonitrile
反応式
Cl[C:2]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:3]=1[C:4]#[N:5].[NH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1.O>COCCO>[C:4]([C:3]1[CH:6]=[C:7]([N+:10]([O-:12])=[O:11])[CH:8]=[CH:9][C:2]=1[N:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1)#[N:5]参加物
5
反応条件
- 温度
- 60 °C
実験手順
A mixture of 2-chloro-5-nitrobenzonitrile (1 g) and piperazine (2.12 g) in ethylene glycol monomethyl ether (5 mL) was heated at 60° C. for 30 minutes. After cooling to room temperature, H2O was added (50 mL) and the solution extracted with CH2Cl2 (3×25 mL). The combined organic layers were washed with H2O, dried over Na2SO4 and evaporated to dryness to give 1.27 g (99%) of the desired compound.
後処理
- temperatureAfter cooling to room temperature
- extractionthe solution extracted with CH2Cl2 (3×25 mL)
- washThe combined organic layers were washed with H2O
- dry with materialdried over Na2SO4
- customevaporated to dryness
出典と根拠
- ORDレコード
- ord-5cc7a83edf3c40e59f8afa3cba7e7001
- 出典データセット
- uspto-grants-2002_06
- 特許番号
- US06399614B1
反応ノート
読み込み中…