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3-Chloro-4-iodoaniline → 3-Allyl-1-(4-amino-2-chlorophenyl)piperidin-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Chloro-4-iodoaniline | HCID 282926 | — |
| 反応物 | 3-Allyl-2-piperidinone | HCID 13380374 | — |
| 生成物 | 3-Allyl-1-(4-amino-2-chlorophenyl)piperidin-2-one | HCID 59586743 | — |
反応手順
Analogously to the process described under example 93A, 6.00 g (23.7 mmol) of 3-chloro-4-iodoaniline and 4.11 g (29.6 mmol) of the compound from example 96A are used to obtain 1.57 g (25% of theory) of the title compound. The purification is effected by suction filtration using silica gel with 2:1→1:2 cyclohexane/ethyl acetate as the eluent.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08198267B2 |
| 出典データセット | uspto-grants-2012_06 |
| ORD ID | ord-1072e6521e71422e8b7d16ab4d45c732 |
| 出典メモ | uspto-grants-2012_06 |