4-Iodo-3-methylaniline → 3-Allyl-1-(4-amino-2-methylphenyl)piperidin-2-one
反応式
I[C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[CH3:9].[CH2:10]([CH:13]1[CH2:18][CH2:17][CH2:16][NH:15][C:14]1=[O:19])[CH:11]=[CH2:12]>>[CH2:10]([CH:13]1[CH2:18][CH2:17][CH2:16][N:15]([C:2]2[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=2[CH3:9])[C:14]1=[O:19])[CH:11]=[CH2:12]参加物
3
実験手順
Analogously to the process described under example 93A, 2.68 g (11.5 mmol) of 4-iodo-3-methylaniline and 2.0 g (14.3 mmol) of the compound from example 96A are used to obtain, after preparative HPLC, 1.31 g (47% of theory) of the title compound.
後処理
- customto obtain
出典と根拠
- ORDレコード
- ord-e6f96413f81047488b5322cb44ec1148
- 出典データセット
- uspto-grants-2012_06
- 特許番号
- US08198267B2
反応ノート
読み込み中…