3-Chloro-2-methylaniline → 1-(3-Chloro-2-methylphenyl)piperazine hydrochloride
反応式
[NH2:1][C:2]1[C:7]([CH3:8])=[C:6]([Cl:9])[CH:5]=[CH:4][CH:3]=1.Cl.Cl[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]Cl>ClC1C=CC=CC=1>[ClH:9].[Cl:9][C:6]1[C:7]([CH3:8])=[C:2]([N:1]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[CH:3]=[CH:4][CH:5]=1参加物
4
実験手順
A mixture of 6-amino-2-chlorotoluene (158.66 g) and bis-(2-chloroethyl)amine hydrochloride (200.0 g) in chlorobenzene (800 mL) was allowed to reflux for 3 days. After cooling, the reaction mixture was filtered and then washed with ether to give the titled compound (244.3 g) as a white powder: 1H NMR (400 MHz, DMSO-d6) δ 2.29 (s, 3H), 3.06 (m, 4H), 3.22 (m, 4H), 7.05 (dd, J=2.0, 6.8 Hz, 1H), 7.17-7.23 (m, 2H), and 9.40 (br s, 2H).
後処理
- temperatureto reflux for 3 days
- temperatureAfter cooling
- filtrationthe reaction mixture was filtered
- washwashed with ether
出典と根拠
- ORDレコード
- ord-04bf5ebc73bc4c2c99e51a4bc15f46e0
- 出典データセット
- uspto-grants-2002_06
- 特許番号
- US06399629B1
反応ノート
読み込み中…