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6-(Propan-2-yl)pyridin-3-amine → 5-benzyloxy-8-fluoro-N-(6-isopropylpyridin-3-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 6-(Propan-2-yl)pyridin-3-amine | HCID 17854288 | — |
| 反応物 | 5-Benzyloxy-8-fluoro-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid | HCID 17854540 | — |
| 生成物 | 5-benzyloxy-8-fluoro-N-(6-isopropylpyridin-3-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide | HCID 17854160 | 88.6% |
反応手順
By the reaction and treatment in the same manner as in Preparation Example 11 using 5-benzyloxy-8-fluoro-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid (2.30 g) and 5-amino-2-isopropylpyridine (1.04 g) as starting materials, 5-benzyloxy-8-fluoro-N-(6-isopropylpyridin-3-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (2.83 g) was obtained. melting point: 184.0° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08198454B2 |
| 出典データセット | uspto-grants-2012_06 |
| ORD ID | ord-be84fb88189349caa9992b3dcbf58368 |
| 出典メモ | uspto-grants-2012_06 |