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p-Chlorophenacyl bromide → 5-(4-Chlorophenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-Chlorophenacyl bromide | HCID 68303 | — |
| 反応物 | O-methyl hydrazinecarbothioate | HCID 10171237 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 5-(4-Chlorophenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one | HCID 329473 | 48.4% |
反応手順
A mixture of 2-bromo-p-chloroacetophenone (9.16 g), methoxythiocarbonylhydrazine (13.0 g) and acetonitrile (75 ml) was refluxed overnight and then cooled and filtered. The light yellow solid was washed with hexane and dried yielding 5-(4-chlorophenyl)-3H,6H-1,3,4-thiadiazin-2-one (4.3 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05728715 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-78ffab45f98b4d54bbf0b4abd3bad247 |
| 出典メモ | uspto-grants-1998_03 |