Methyl 4-(bromomethyl)-3-chlorobenzoate → Methyl 3-chloro-4-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]benzoate

HRID 2186045ノート

反応式

HRID 2186045 の反応式
Br[CH2:2][C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][C:4]=1[Cl:13].[C:14]1(=[O:24])[NH:18][C:17](=[O:19])[C:16]2=[CH:20][CH:21]=[CH:22][CH:23]=[C:15]12.[K]>CN(C)C=O>[C:14]1(=[O:24])[N:18]([CH2:2][C:3]2[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][C:4]=2[Cl:13])[C:17](=[O:19])[C:16]2=[CH:20][CH:21]=[CH:22][CH:23]=[C:15]12

参加物

4

反応物 2

HCID 22027761Methyl 4-(bromomethyl)-3-chlorobenzoateHCID 24194345Phthalimide potassium salt

生成物 1

HCID 22451715Methyl 3-chloro-4-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]benzoate

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
85 °C

実験手順

A mixture of methyl 4-bromomethyl-3-chlorobenzoate 10 g, 38 mmol) and potassium phthalimide (9.85 g, 53 mmol) in dimethylformamide (65 mL) was stirred and heated to 85° C. for 2 h. The hot mixture was poured into ice water and the resulting solid was filtered, washed sequentially with water, ethanol and a small amount of ether and dried to give the title compound.

後処理

  1. filtrationthe resulting solid was filtered
  2. washwashed sequentially with water, ethanol
  3. dry with materiala small amount of ether and dried

出典と根拠

ORDレコード
ord-e1b64eb5c6974cd9b8f96fea8b134ce1
出典データセット
uspto-grants-2002_06
特許番号
US06403578B1

反応ノート

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