Ammonia → 1-Benzyl-4-bromo-5-aminobenzimidazole

HRID 2186085ノート

反応式

HRID 2186085 の反応式
[CH2:1]([N:8]1[C:12]2[CH:13]=[CH:14][C:15]([NH2:17])=[CH:16][C:11]=2[N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Br:18]Br.N.CO>CC(O)=O>[CH2:1]([N:8]1[C:12]2[CH:13]=[CH:14][C:15]([NH2:17])=[C:16]([Br:18])[C:11]=2[N:10]=[CH:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

6

反応物 4

HCID 222AmmoniaHCID 887MethanolHCID 24408BromineHCID 10890581-Benzyl-1H-benzimidazol-5-amine

生成物 1

HCID 183798211-Benzyl-4-bromo-5-aminobenzimidazole収率 60%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒2 回

実験手順

To a solution of 1-benzyl-5-aminobenzimidazole (1.0 g, 5.0 mmol) in 40 ml of AcOH was added solution of Br2 in AcOH until it produces a precipitate. The reaction mixture was concentrated in vacuo to provide a brown solid which was subjected to column chromatography (5% NH3 sat'd MeOH/CHC13) to provide 0.90g (2.5 mmol, 60%) of the product.

後処理

  1. customproduces a precipitate
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. customto provide a brown solid which

出典と根拠

ORDレコード
ord-b348c9b5c7bf48378f0db12df33a228f
出典データセット
uspto-grants-2002_06
特許番号
US06403626B1

反応ノート

読み込み中…