関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Bromine | HCID 24408 | — |
| 反応物 | 2-Isopropyl-1H-benzo[d]imidazol-5-amine | HCID 820749 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | HCID 178439939 | HCID 178439939 | 95% |
反応手順
To a solution of 0.95 g (5.4 mmol) of 2-isopropyl-5-aminobenzimidazole in 50 ml of AcOH was added 0.19 ml (3.7 mmol) of Br2 dropwise and resulting reaction mixture was stirred for 1 h at 25° C. Reaction mixture was concentrated in vacuo and purified on silica gel column chromatography (5% MeOH/EtOAC) to yield 0.89 g (3.5 mmol, 95%) of the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06403626B1 |
|---|
| 出典データセット | uspto-grants-2002_06 |
|---|
| ORD ID | ord-dc3c363b4cd24f84b4042d9f1270f685 |
|---|
| 出典メモ | uspto-grants-2002_06 |
|---|
