Hydrochloric Acid → 4-(5-Chlorobenzofuran-2-sulfonyl)-1-(piperidin-4-ylmethyl)-2-piperazinone hydrochloride

HRID 2186160ノート

反応式

HRID 2186160 の反応式
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][N:15]2[CH2:20][CH2:19][N:18]([S:21]([C:24]3[O:25][C:26]4[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][C:27]=4[CH:28]=3)(=[O:23])=[O:22])[CH2:17][C:16]2=[O:34])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>C(OCC)(=O)C.CO>[ClH:33].[Cl:33][C:30]1[CH:31]=[CH:32][C:26]2[O:25][C:24]([S:21]([N:18]3[CH2:19][CH2:20][N:15]([CH2:14][CH:11]4[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]4)[C:16](=[O:34])[CH2:17]3)(=[O:23])=[O:22])=[CH:28][C:27]=2[CH:29]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 234474431-[1-(Tert-butoxycarbonyl)piperidin-4-ylmethyl]-4-(5-chlorobenzofuran-2-sulfonyl)-2-piperazinone

生成物 1

HCID 234473124-(5-Chlorobenzofuran-2-sulfonyl)-1-(piperidin-4-ylmethyl)-2-piperazinone hydrochloride収率 193.7%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To 1-[1-(tert-butoxycarbonyl)piperidin-4-ylmethyl]-4-(5-chlorobenzofuran-2-sulfonyl)-2-piperazinone (270 mg) were added 4N hydrochloric acid in ethyl acetate (8 ml) and methanol (2 ml), and the mixture was stirred at room temperature for 30 minutes. The reaction solution was concentrated to give 4-(5-chlorobenzofuran-2-sulfonyl)-1-(piperidin-4-ylmethyl)-2-piperazinone hydrochloride (229 mg).

後処理

  1. concentrationThe reaction solution was concentrated

出典と根拠

ORDレコード
ord-a0f61b2327b24fb1adc7d2b41d9dd5f9
出典データセット
uspto-grants-2002_06
特許番号
US06403595B1

反応ノート

読み込み中…