Morpholine → 7-Bromo-4-methoxy-2-(morpholin-4-yl)-benzooxazole

反応式

[Br:1][C:2]1[C:10]2[O:9][C:8](SC)=[N:7][C:6]=2[C:5]([O:13][CH3:14])=[CH:4][CH:3]=1.[NH:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1>>[Br:1][C:2]1[C:10]2[O:9][C:8]([N:15]3[CH2:20][CH2:19][O:18][CH2:17][CH2:16]3)=[N:7][C:6]=2[C:5]([O:13][CH3:14])=[CH:4][CH:3]=1

参加物

反応物 2

HCID 8083Morpholine

HCID 224566517-Bromo-4-methoxy-2-methylsulfanylbenzooxazole

生成物 1

HCID 224566577-Bromo-4-methoxy-2-(morpholin-4-yl)-benzooxazole

反応条件

温度: 80 °C

実験手順

A mixture of 7-bromo-4-methoxy-2-methylsulfanylbenzooxazole (10.0 g) and morpholine (6.6 ml) were heated at 80° C. for 18 hours. Purification by chromatography on silica eluting with 20-100% ethyl acetate in heptane afforded the title compound as an off-white solid (11.6 g).

後処理

customPurification by chromatography on silica eluting with 20-100% ethyl acetate in heptane

出典と根拠

ORDレコード: ord-dbf4b158d40c4f529ad1063a144de0d7
出典データセット: uspto-grants-2002_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06403791B1

反応ノート

読み込み中…