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5-Amino-1-methyl-1H-pyrazole-4-carbonitrile → 4-Difluoromethoxy-2-(piperidin-1-yl)-benzooxazole-7-carboxylic acid (4-cyano-2-methyl-2H-pyrazol-3-yl)-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Amino-1-methyl-1H-pyrazole-4-carbonitrile | HCID 219740 | — |
| 反応物 | 4-Difluoromethoxy-2-(piperidin-1-yl)-benzooxazole-7-carboxylic acid 4-nitro-phenyl ester | HCID 69838534 | — |
| 生成物 | 4-Difluoromethoxy-2-(piperidin-1-yl)-benzooxazole-7-carboxylic acid (4-cyano-2-methyl-2H-pyrazol-3-yl)-amide | HCID 10201983 | 14.9% |
反応手順
Starting from 4-difluoromethoxy-2-(piperidin-1-yl)-benzooxazole-7-carboxylic acid 4-nitro-phenyl ester (0.35 g) and 5-amino-1-methyl-1H-pyrazole-4-carbonitrile (0.197 g). Purification by column chromatography on silica eluting with 50% ethyl acetate in heptane afforded the title compound as a white solid (50 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06403791B1 |
| 出典データセット | uspto-grants-2002_06 |
| ORD ID | ord-c96463d8c8374bc2adb91e3d0af30960 |
| 出典メモ | uspto-grants-2002_06 |