Sulfuric Acid → 3-Hydroxy-2-naphthoic acid

反応式

[OH:1][C:2]1[C:11]([C:12]([O-:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=1.[Na+].S(=O)(=O)(O)O>>[OH:1][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=1

参加物

反応物 2

HCID 1118Sulfuric Acid

HCID 23672297Sodium 3-hydroxy-2-naphthoate

生成物 1

HCID 71043-Hydroxy-2-naphthoic acid収率 90%

反応条件

温度: 160 °C

実験手順

To a 1 L autoclave, 800 g of aqueous solution containing 100 g of sodium 2-hydroxynaphthalene-3-carboxylate prepared by means of the Kolbe-Schmitt method was fed and heated to 160° C. An aqueous sulfuric acid solution (72%) was added dropwise to the solution over 50 minutes to adjust the pH of the mixture to 3.5. Then, the mixture was cooled to 80° C. at the rate of 0.4° C./min. At the same temperature, the mixture was filtrated to give 80.6 g of crystalline 2-hydroxynaphthalene-3-carboxylic acid.

後処理

customprepared by means of the Kolbe-Schmitt method
temperatureThen, the mixture was cooled to 80° C. at the rate of 0.4° C./min
filtrationAt the same temperature, the mixture was filtrated

出典と根拠

ORDレコード: ord-40d5e710604c424099929d9650a38174
出典データセット: uspto-grants-2002_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06403827B1

反応ノート

読み込み中…

参加物