Potassium Hydroxide → 2-Methoxy-3-methylbenzoic acid

HRID 2186637

反応式

HRID 2186637 の反応式
[CH3:1][O:2][C:3]1[C:12]([CH3:13])=[CH:11][CH:10]=[CH:9][C:4]=1[C:5]([O:7]C)=[O:6].[OH-].[K+]>CO.O>[CH3:1][O:2][C:3]1[C:12]([CH3:13])=[CH:11][CH:10]=[CH:9][C:4]=1[C:5]([OH:7])=[O:6]

参加物

5

反応物 2

HCID 14797Potassium HydroxideHCID 13229229Methyl 2-methoxy-3-methylbenzoate

生成物 1

HCID 9523962-Methoxy-3-methylbenzoic acid収率 95%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

To a solution of 2 (1.19 mol) in a mixture of methanol (2 L) and water (0.5 L), potassium hydroxide pellets (100 gram, 1.5 mol) were added under cooling. The mixture was refluxed overnight and evaporated to dryness. The residue was dissolved in water (0.5 L) and acidified with HCl 6N. The product precipitated and 189 g of product was collected as white crystals. Yield 95%. 1H NMR (500 MHz, CDCl3, 25° C.) δ: 2.234 (s, 3H, CH3), 3.717 (s, 3H, OCH3), 7.062 (t, J=7.5, 1H, ArH), 7.365 (d, J=7.5, 1H, ArH), 7.496 (d, J=7.5, 1H, ArH).

後処理

  1. additionwere added
  2. temperatureunder cooling
  3. temperatureThe mixture was refluxed overnight
  4. customevaporated to dryness
  5. dissolutionThe residue was dissolved in water (0.5 L)
  6. customThe product precipitated
  7. custom189 g of product was collected as white crystals

出典と根拠

ORDレコード
ord-dbaf181f786043bd93d9666b8a8a3bf8
出典データセット
uspto-grants-2002_06
特許番号
US06406297B1

関連ノート

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