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2-Nitrotoluene → Benzaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Nitrotoluene | HCID 6944 | — |
| 反応物 | 4-Chlorobenzaldehyde | HCID 7726 | — |
| 反応物 | Potassium Fluoride | HCID 522689 | — |
| 反応物 | Tetrakis(diethylamino)phosphonium bromide | HCID 11036771 | — |
| 溶媒 | O-Xylene | HCID 7237 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | Benzaldehyde | HCID 240 | — |
| 生成物 | 4-Fluorobenzaldehyde | HCID 68023 | — |
反応手順
At 60° C., a solution of 12.0 g (0.03 mol) of tetrakis(diethylamino)phosphonium bromide in 12 g of N-methylpyrrolidone (NMP), 174.3 g (3 mol) of potassium fluoride, 4.1 g (0.03 mol) of nitrotoluene and 18 ml of xylene are successively added to 421.7 g (3 mol) of 4-chlorobenzaldehyde (4-CBAL). The reaction mixture is dried by azeotropic distillation of the xylene under reduced pressure. After 24 hours at 1 90° C., the formation of 4-fluorobenzaldehyde (4-FBAL) and of benzaldehyde produced by dehalogenation, and the conversion of the reaction are determined by gas chromatography.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06407029B1 |
| 出典データセット | uspto-grants-2002_06 |
| ORD ID | ord-952e4b891acd47d899810b31b7163350 |
| 出典メモ | uspto-grants-2002_06 |