関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | (2s,3As,6as)-1-[(s)-2-[[(s)-1-(ethoxycarbonyl)-3-phenylpropyl]-amino]propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid benzyl ester maleic acid salt | HCID 10121882 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | Ramipril | HCID 5362129 | — |
反応手順
A 1.0 g portion of (2S,3aS,6aS)-1-[(S)-2-[[(S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid benzyl ester maleic acid salt 1 was placed into 100 mL of dichloromethane, and was cooled to 0-5° C. Triethylamine (0.19 g) was added to the mixture. The resulting mixture was washed with water, and the organic phase was evaporated to give an oil. This oil was deprotected using hydrogenolysis, as per examples stated in EP 079022 to give Ramipril as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06407262B1 |
|---|
| 出典データセット | uspto-grants-2002_06 |
|---|
| ORD ID | ord-2ba52ce1ab474547a63de27377c6daf5 |
|---|
| 出典メモ | uspto-grants-2002_06 |
|---|
