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HRID 218728作成日：2026年10月26日

2-(Chloromethyl)-6-methylpyridine → 5-benzyloxy-N-(6-isopropylpyridin-3-yl)-N-({1-[(6-methylpyridin-2-yl)methyl]pyrazol-4-yl}methyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide

https://huagongshe.com/reaction/218728

反応式

関与物質

役割名称HCID仕込み量
反応物2-(Chloromethyl)-6-methylpyridineHCID 76546—
反応物5-benzyloxy-N-(6-isopropylpyridin-3-yl)-N-[(pyrazol-4-yl)methyl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide hydrochlorideHCID 67183027—
生成物5-benzyloxy-N-(6-isopropylpyridin-3-yl)-N-({1-[(6-methylpyridin-2-yl)methyl]pyrazol-4-yl}methyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamideHCID 5919118484.9%

反応手順

By the reaction and treatment in the same manner as in Example 271 using 5-benzyloxy-N-(6-isopropylpyridin-3-yl)-N-[(pyrazol-4-yl)methyl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide hydrochloride (0.78 g) and 2-chloromethyl-6-methylpyridine (0.43 g) as starting materials, 5-benzyloxy-N-(6-isopropylpyridin-3-yl)-N-({1-[(6-methylpyridin-2-yl)methyl]pyrazol-4-yl}methyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (0.75 g) was obtained.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08198454B2
出典データセットuspto-grants-2012_06
ORD IDord-3059b0c8822c4e11969779505285b548
出典メモuspto-grants-2012_06