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HRID 218741作成日：2026年10月26日

2-(Chloromethyl)-5-methoxypyridine → N-(6-isopropylpyridin-3-yl)-N-({1-[(5-methoxypyridin-2-yl)methyl]pyrazol-4-yl}methyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide dihydrochloride

https://huagongshe.com/reaction/218741

反応式

関与物質

役割名称HCID仕込み量
反応物2-(Chloromethyl)-5-methoxypyridineHCID 14517153—
反応物N-(6-isopropylpyridin-3-yl)-N-[(pyrazol-4-yl)methyl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide hydrochlorideHCID 67183012—
生成物N-(6-isopropylpyridin-3-yl)-N-({1-[(5-methoxypyridin-2-yl)methyl]pyrazol-4-yl}methyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide dihydrochlorideHCID 6718309373.8%

反応手順

By the reaction and treatment in the same manner as in Example 334 using N-(6-isopropylpyridin-3-yl)-N-[(pyrazol-4-yl)methyl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide hydrochloride (0.95 g) and 2-chloromethyl-5-methoxypyridine (0.83 g) as starting materials, N-(6-isopropylpyridin-3-yl)-N-({1-[(5-methoxypyridin-2-yl)methyl]pyrazol-4-yl}methyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide dihydrochloride (0.97 g) was obtained.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08198454B2
出典データセットuspto-grants-2012_06
ORD IDord-7f83b037ccda47028302a532b07f0e4d
出典メモuspto-grants-2012_06