関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | p-Chlorothiophenol | HCID 7815 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Bromo-4'-methylacetophenone | HCID 69272 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-(4-Chlorophenylthio)-1-(4-methylphenyl)ethanone | HCID 2745101 | 82.3% |
反応手順
A mixture of 10.0 g (47 mmol) 4-methylphenacyl bromide, 6.8 g (47 mmol) 4-chlorothiophenol, and 6.5 g (47 mmol) anhydrous potassium carbonate in 100 ml dry DMF was stirred for 3 h at 80° C. It was filtered and the filtrate was concentrated under reduced pressure. The concentrate was stirred in water, and the resulting solid was filtered off, washed with water, and recrystallized from ethanol to give 10.7 g (82%) of the crude title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06410562B1 |
|---|
| 出典データセット | uspto-grants-2002_06 |
|---|
| ORD ID | ord-44f50bf5ebd84717b40adb93417d9ac3 |
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| 出典メモ | uspto-grants-2002_06 |
|---|
