Formamide → 5,6-Dihydro-3H-pyrano[4',3':4,5]thieno[2,3-D]pyrimidin-4(8H)-one
反応式
C([O:3][C:4]([C:6]1[C:14]2[CH2:13][CH2:12][O:11][CH2:10][C:9]=2[S:8][C:7]=1[NH2:15])=O)C.[CH:16]([NH2:18])=O>>[N:15]1[C:7]2[S:8][C:9]3[CH2:10][O:11][CH2:12][CH2:13][C:14]=3[C:6]=2[C:4](=[O:3])[NH:18][CH:16]=1参加物
3
実験手順
2-Amino-4,5-dihydro-7H-thieno[2,3-c]pyran-3-carboxylic acid ethyl ester (26 g, 0.114 mol) was dissolved in formamide (200 ml) and the resulting mixture was heated at reflux temperature for 1.5 h. After cooling to room temperature the precipitate was filtered off, washed with water (2×80 ml) and dried in vacuo at 50° C. for 18 h which afforded 10.0 g (42%) of 5,6-dihydro-8H-pyrano[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-one as a solid.
後処理
- temperaturethe resulting mixture was heated
- temperatureat reflux temperature for 1.5 h
- filtrationwas filtered off
- washwashed with water (2×80 ml)
- customdried in vacuo at 50° C. for 18 h which
出典と根拠
- ORDレコード
- ord-7f9c72ec42f545d5a52da23ce8ac4855
- 出典データセット
- uspto-grants-2002_06
- 特許番号
- US06410586B1
反応ノート
読み込み中…