Veratrole → Methyl 4-(3,4-dimethoxybenzoyl)benzoate

HRID 2187956ノート

反応式

HRID 2187956 の反応式
[Cl-].[Al+3].[Cl-].[Cl-].[Cl-].[C:6]([O:17][CH3:18])(=[O:16])[C:7]1[CH:15]=[CH:14][C:10]([C:11]([O-:13])=O)=[CH:9][CH:8]=1.[CH3:19][O:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[O:27][CH3:28]>ClCCl>[CH3:19][O:20][C:21]1[CH:26]=[C:25]([CH:24]=[CH:23][C:22]=1[O:27][CH3:28])[C:11]([C:10]1[CH:9]=[CH:8][C:7]([C:6]([O:17][CH3:18])=[O:16])=[CH:15][CH:14]=1)=[O:13]

参加物

5

反応物 3

HCID 7043VeratroleHCID 6451240Aluminum(III) ChlorideHCID 22493623Monomethyl terephthalate chloride

生成物 1

HCID 22645197Methyl 4-(3,4-dimethoxybenzoyl)benzoate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒3 回

実験手順

2.1 g (15.72 mmol) of aluminum chloride, a solution of 2.39 g (12.02 mmol) of monomethyl terephthalate chloride dissolved in 2 ml of dichloromethane and 1.2 ml (9.25 mmol) of 1,2-dimethoxybenzene dissolved in 2 ml of dichloromethane were added to 10 ml of dichloromethane, and they were stirred overnight. The reaction solution was poured into 5 g of 1 N hydrochloric acid/ice. After the treatment with chloromethane as the extraction solvent in an ordinary manner, the solvent was evaporated, and the obtained residue was washed with ethyl acetate and dichloromethane to obtain the title compound.

後処理

  1. customAfter the treatment with chloromethane as the extraction solvent in an ordinary manner, the solvent was evaporated
  2. washthe obtained residue was washed with ethyl acetate and dichloromethane

出典と根拠

ORDレコード
ord-55990dd6ae334c3eaf48594d903efc95
出典データセット
uspto-grants-2002_06
特許番号
US06410538B2

反応ノート

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