Diethylene Glycol Monobutyl Ether → 5-benzyloxy-N-({1-[2-(2-butoxyethoxy)ethyl]pyrazol-4-yl}methyl)-N-(6-isopropylpyridin-3-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide
反応式
[CH2:1]([O:5][CH2:6][CH2:7][O:8][CH2:9][CH2:10]O)[CH2:2][CH2:3][CH3:4].[CH2:12]([O:19][C:20]1[CH:29]=[CH:28][CH:27]=[C:26]2[C:21]=1[CH2:22][CH2:23][CH2:24][CH:25]2[C:30]([N:32]([C:39]1[CH:40]=[N:41][C:42]([CH:45]([CH3:47])[CH3:46])=[CH:43][CH:44]=1)[CH2:33][C:34]1[CH:35]=[N:36][NH:37][CH:38]=1)=[O:31])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[CH2:12]([O:19][C:20]1[CH:29]=[CH:28][CH:27]=[C:26]2[C:21]=1[CH2:22][CH2:23][CH2:24][CH:25]2[C:30]([N:32]([CH2:33][C:34]1[CH:35]=[N:36][N:37]([CH2:10][CH2:9][O:8][CH2:7][CH2:6][O:5][CH2:1][CH2:2][CH2:3][CH3:4])[CH:38]=1)[C:39]1[CH:40]=[N:41][C:42]([CH:45]([CH3:47])[CH3:46])=[CH:43][CH:44]=1)=[O:31])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1参加物
3
反応物 2
生成物 1
実験手順
By the reaction and treatment of diethylene glycol monobutyl ether (1.0 mL) and 5-benzyloxy-N-(6-isopropylpyridin-3-yl)-N-[(pyrazol-4-yl)methyl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide (0.96 g) in the same manner as in Example 394, 5-benzyloxy-N-({1-[2-(2-butoxyethoxy)ethyl]pyrazol-4-yl}methyl)-N-(6-isopropylpyridin-3-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (1.94 g) was obtained.