化工社化工社 化学情報印刷レポート · 研究参考用
Benzyl Bromide → 1-Benzyl-3-cyanoindazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzyl Bromide | HCID 7498 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 1H-Indazole-3-carbonitrile | HCID 437556 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 1-Benzyl-3-cyanoindazole | HCID 15840355 | 79.6% |
反応手順
420 mg of NaH (60% in oil, 10.3 mmol) were added in portions to 1.0 g of 3-cyanoindazole (7.0 mmol) and 1.7 ml of benzyl bromide (14.0 mmol) in 6 ml of THF, and the mixture was stirred at room temperature for 15 hours. The reaction was quenched with 2 drops of water, the mixture was concentrated and the residue was chromatographed (SiO2; petroleum ether:ethyl acetate 3:1). 1.3 g of a solid were obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06410740B1 |
| 出典データセット | uspto-grants-2002_06 |
| ORD ID | ord-a0e988eaa112489a813815b691463177 |
| 出典メモ | uspto-grants-2002_06 |