化工社化工社 化学情報印刷レポート · 研究参考用
3-(4-Chlorobenzoyl)propionic acid → 2-(Carboxymethoxy)-5-[(2S)-2-{[(3R)-3-carboxy-4-phenylbutanoyl]amino}-3-oxo-3-(pentylamino)propyl]benzoic Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(4-Chlorobenzoyl)propionic acid | HCID 77604 | — |
| 反応物 | 3-Iodo-L-Tyrosine | HCID 439744 | — |
| 反応物 | Ethyl 5-[(2S)-2-Amino-3-(benzyloxy)-3-oxopropyl]-2-(2-ethoxy-2-oxoethoxy)benzoate | HCID 57257659 | — |
| 反応物 | Ethyl 5-{(2S)-3-(Benzyloxy)-2-[(tert-butoxycarbonyl)amino]-3-oxopropyl}-2-(2-ethoxy-2-oxoethoxy)benzoate | HCID 70160131 | — |
| 反応物 | Ethyl 5-((2S)-3-(Benzyloxy)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-oxopropyl)-2-(2-ethoxy-2-oxoethoxy)benzoate | HCID 70160837 | — |
| 生成物 | 2-(Carboxymethoxy)-5-[(2S)-2-{[(3R)-3-carboxy-4-phenylbutanoyl]amino}-3-oxo-3-(pentylamino)propyl]benzoic Acid | HCID 70160942 | — |
反応手順
The title compound was prepared in analogy with the preparation of the compound of Example 151 above. MS (FAB) m/z (rel. intensity) 543 (MH+, 25), 544 (9), 543 (25), 309 (15), 263 (9), 233 (10), 231 (48), 154 (99), 137 (58), 109 (15), 91 (16). MS (FAB) m/z (rel. intensity) 543 (MH+, 99), 565 (20), 544 (33), 543 (99), 238 (25), 117 (16), 107 (16), 88 (58), 43 (23), 41 (16), 23 (17). HRMS (FAB) calcd for C28H34N2O9+H1 543.2343, found 543.2353. Anal. Calcd for C28H34N2O9: C, 61.98; H, 6.32; N, 5.16. Found: C, 60.35; H, 6.35; N, 4.89.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06410585B1 |
| 出典データセット | uspto-grants-2002_06 |
| ORD ID | ord-0849198a13874ac2825be787f584b42e |
| 出典メモ | uspto-grants-2002_06 |