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Tetrahydrofuran → 2-(4-Methylbutyloxy)acetaldehyde diethylacetal
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | Ethane, 2-bromo-1,1-diethoxy- | HCID 74852 | — |
| 反応物 | (+)-2-Pentanol | HCID 2724896 | — |
| 生成物 | 2-(4-Methylbutyloxy)acetaldehyde diethylacetal | HCID 19930625 | — |
反応手順
35 g of (S)-2-pentanol was dissolved in tetrahydrofuran, and 16 g of 60% sodium hydride was added thereto. After stirring for 30 minutes, 80 g of bromoacetaldehyde diethylacetal was added thereto, and the mixture was refluxed for 6 hours. After the reaction solution were concentrated and water and ether was added thereto, the mixture was shaken for mixing. The organic layer was collected and was dried with magnesium sulfate to remove the solvent off. Purification was carried out by column chromatography to obtain 2-(4-methylbutyloxy)acetaldehyde diethylacetal (54).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05425897 |
| 出典データセット | uspto-grants-1995_06 |
| ORD ID | ord-2eb3063371754bbd90900474ffe7d134 |
| 出典メモ | uspto-grants-1995_06 |