Cyclopentylamine → 2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine

反応式

C1(N)CCCC1.BrC1C(Cl)=NC(Cl)=NC=1.[Cl:16][C:17]1[N:18]=[CH:19][C:20]2[CH:25]=[CH:24][N:23]([CH:26]([CH2:29][CH3:30])[CH2:27][CH3:28])[C:21]=2[N:22]=1>>[Cl:16][C:17]1[N:18]=[CH:19][C:20]2[CH:25]=[CH:24][N:23]([CH:26]3[CH2:29][CH2:30][CH2:28][CH2:27]3)[C:21]=2[N:22]=1

参加物

反応物 3

HCID 2906Cyclopentylamine

HCID 2899735-Bromo-2,4-dichloropyrimidine

HCID 580159322-Chloro-7-(pentan-3-yl)-7H-pyrrolo[2,3-d]pyrimidine

生成物 1

HCID 866373422-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine

実験手順

2-chloro-7-(cyclopentyl)-7H-pyrrolo[2,3-d]pyrimidine is prepared from cyclopentyl amine and 5-bromo-2,4-dichloropyrimidine using a method similar to that for the preparation of 2-chloro-7-(1-ethyl-propyl)-7H-pyrrolo[2,3-d]pyrimidine given in example 1.

出典と根拠

ORDレコード: ord-c81192b723b749dda9fac699d766b369
出典データセット: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08324225B2

反応ノート

読み込み中…