Hydrochloric Acid → Hydrochloric Acid

HRID 2189910ノート

反応式

HRID 2189910 の反応式
C(OC(=O)[NH:7][C@H:8]([C:10]1[N:15]=[CH:14][C:13]([F:16])=[CH:12][N:11]=1)[CH3:9])(C)(C)C.[ClH:18]>C(Cl)Cl.O1CCOCC1>[F:16][C:13]1[CH:12]=[N:11][C:10]([C@@H:8]([NH2:7])[CH3:9])=[N:15][CH:14]=1.[ClH:18]

参加物

6

反応物 2

HCID 313Hydrochloric AcidHCID 58367398(S)-tert-butyl 1-(5-fluoropyrimidin-2-yl)ethylcarbamate

生成物 2

HCID 313Hydrochloric AcidHCID 55285341(S)-1-(5-Fluoropyrimidin-2-YL)ethanamine

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 312751,4-Dioxane溶媒

実験手順

To a solution of (S)-tert-butyl-1-(5-fluoropyrimidin-2-yl)ethylcarbamate (Method 56, 0.21 g, 0.87 mmol) in DCM (5 ml) was added HCl (1.3 ml, 5.2 mmol) in dioxane. The reaction was stirred at room temperature for 3 hours. The solvent was removed give (S)-1-(5-fluoropyrimidin-2-yl)ethanamine as HCl salt as white solid (quantitative). MS: Calcd.: 141. Found: [M+H]+ 142.

後処理

  1. customThe solvent was removed

出典と根拠

ORDレコード
ord-e2872520c8f443daa6abc12478dc90c4
出典データセット
uspto-grants-2012_12
特許番号
US08324252B2

反応ノート

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