2,4,6-Tribromophenol → HCID 3303004、化合物

HRID 2189960

反応式

HRID 2189960 の反応式
[Br:1][C:2]1[CH:7]=[C:6]([Br:8])[CH:5]=[C:4]([Br:9])[C:3]=1[OH:10].Cl[CH2:12][C:13]([CH3:15])=[O:14].C(=O)([O-])[O-].[K+].[K+].CN(C=O)C>O>[Br:1][C:2]1[CH:7]=[C:6]([Br:8])[CH:5]=[C:4]([Br:9])[C:3]=1[O:10][CH2:12][C:13](=[O:14])[CH3:15]

参加物

6

反応物 4

HCID 14832,4,6-TribromophenolHCID 6228DimethylformamideHCID 6571ChloroacetoneHCID 11430Potassium Carbonate

生成物 1

HCID 3303004HCID 3303004、化合物収率 97%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
27 °C

実験手順

A mixture of 5 g 2,4,6-tribromophenol (15 mmol), 1.4 g 1-chloroacetone (15 mmol), 4.16 g anhydrous potassium carbonate (30 mmol) and 20 ml DMF is stirred at 27° C. Completion of the reaction is confirmed by TLC. The reaction mass is diluted with water and extracted with ethylacetate The organic layer is washed with water and brine, dried over anhydrous sodium sulphate and concentrated to obtain 5.6 g 1-(2,4,6-tribromo-phenoxy)-propan-2-one (97%).

後処理

  1. extractionextracted with ethylacetate The organic layer
  2. washis washed with water and brine
  3. dry with materialdried over anhydrous sodium sulphate
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-38af585a78e94ac3a9c44895c8a11a23
出典データセット
uspto-grants-2012_12
特許番号
US08324263B2

関連ノート

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