Ethyl 4-bromo-5-(4-fluorophenyl)furan-2-carboxylate → Ethyl 4-(3-chlorophenyl)-5-(4-fluorophenyl)furan-2-carboxylate

HRID 2190119ノート

反応式

HRID 2190119 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:10]=[C:11]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[O:12][C:13]=2[C:14]2[CH:19]=[CH:18][CH:17]=[C:16](C#N)[CH:15]=2)[CH:5]=[C:6](F)[CH:7]=1.BrC1C=C(C(OCC)=O)OC=1C1C=CC([F:39])=CC=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:10]=[C:11]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[O:12][C:13]=2[C:14]2[CH:19]=[CH:18][C:17]([F:39])=[CH:16][CH:15]=2)[CH:5]=[CH:6][CH:7]=1

参加物

3

反応物 2

HCID 58064766Ethyl 4-bromo-5-(4-fluorophenyl)furan-2-carboxylateHCID 58064795Ethyl 4-(3-chloro-5-fluorophenyl)-5-(3-cyanophenyl)furan-2-carboxylate

生成物 1

HCID 58064804Ethyl 4-(3-chlorophenyl)-5-(4-fluorophenyl)furan-2-carboxylate

実験手順

The synthesis of the title compound takes place in analogy to the synthesis of the compound from Example 11A starting with the compound from Example 7A. Extraction is carried out with dichloromethane and purification with the mobile phase cyclohexane/ethyl acetate (30:1). 4.12 g (41% of theory) of the title compound with a purity of 50% are obtained.

後処理

  1. extractionExtraction
  2. customis carried out with dichloromethane and purification with the mobile phase cyclohexane/ethyl acetate (30:1)

出典と根拠

ORDレコード
ord-a1905e68fcb840e5a4eebf8afbb13c80
出典データセット
uspto-grants-2012_12
特許番号
US08324268B2

反応ノート

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